In mice, intestinal epithelial cells (IECs) are a primary site of Salmonella infection, and epithelial-intrinsic expression of NAIP or NLRC4 is both necessary and sufficient to restrict bacterial burden, indicating a central role for the NAIP/NLRC4 inflammasome in mucosal immunity [40,41]. The gene discussed is NAIP; the disease is Salmonella Infections.