Therefore, we performed a case–control, cross-sectional study comparing the levels of eight adipokine-related markers (adiponectin, leptin, resistin, chemerin, adipsin, thrombospondin-1 [TSP-1], paraoxonase-1 [PON-1], and myeloperoxidase [MPO]) in MM patients and healthy controls and evaluated their associations with established prognostic parameters, disease stage, treatment response, and CRAB criteria (hypercalcaemia, renal failure, anemia, and bone lesions). This evidence concerns the gene THBS1 and Renal insufficiency.