In this context, Oka et al., while confirming low-level immunogenicity due to defective expression of MHC-1 and β2M in human primary nodular BCC, also observed increased expression of the transcription factor, Forkhead box c1 (Foxc1) in a BCC cell line (UW-BCC1) [66]. This evidence concerns the gene FOXC1 and skin basal cell carcinoma.