Dysregulation of presentation of tumor antigens/neoantigens is a significant mechanism of failure of recruitment/activation of anti-tumor cytotoxic T-cells in BCC, which is a consequence of down-regulation of MHC-1 and/or its key structural component, β2 microglobulin (β2M) [73,74], key mediators of antigen presentation. Here, B2M is linked to neoplasm.