To further compare the predictive potential among age, initial renal function represented by creatinine levels, and MPO-ANCA titres for an unwanted advance to renal failure, multivariable Cox proportional hazard analysis with these three variables for progression to ESKD was conducted, such as age, serum creatinine levels, and MPO-ANCA titre ≤ 81.0 IU/mL at diagnosis. This evidence concerns the gene MPO and Renal insufficiency.