Pyrvinium inhibited Wnt/β-catenin, triggered apoptosis, and potentiated cisplatin in CC systems [52]; closantel reduced angiogenesis and tumor growth in zebrafish xenografts [53]; monensin curtailed tumor growth in vivo while targeting Wnt/β-catenin [88]; and nifuroxazide suppressed STAT3 with pro-apoptotic effects [61]. This evidence concerns the gene STAT3 and neoplasm.