Although beyond the scope of this review, the same SNP is associated with an increased risk of various cancers and is predictive of clinical outcomes, with reduced binding to microRNA-199a, a negative regulator of HIF-1 levels that binds to the 3′-UTR [121,122] This suggests that elevated HIF-1 protein levels may offer protection against coronary ischemic events but could predispose patients to cancer progression, potentially mediated by microRNA-199a. Here, HIF1A is linked to cancer.