In their cohort of 2909 participants without known PAD or coronary artery disease from the Chronic Renal Insufficiency Cohort (CRIC) who were followed for a mean of 7.4 years, elevated hs-cTnT was a strong, independent predictor of future PAD, even after adjustment for traditional cardiovascular risk factors. The gene discussed is TNNT2; the disease is peripheral arterial disease.