The rs1333049-C allele, located in the CDKN2B-AS1 intron, was found to be associated with a poor response to metformin (absolute HbA1c level changed by less than 0.5% from baseline after a three-month course of treatment) in Filipinos with T2DM [296]. This evidence concerns the gene CDKN2B and type 2 diabetes mellitus.