rs1333049have shown significant association with poor metformin responsers1333049 is found to be significantly associated with HbA1c level in Mexican nonobese T2DM patientsrs1333049 (SNP) in CDKN2B-AS1, located in the 9p21 region. is associated with advanced carotid artery atherosclerosis. The gene discussed is CDKN2B; the disease is type 2 diabetes mellitus.