AKT1 and type 2 diabetes mellitus: It was also found that carriers of the G allele and the GG genotype of the rs3746444 polymorphism, located in the stem loop miR-499 precursor, the mature form of which is involved in the PI3K/AKT signaling pathway and glycogen synthesis, have an increased risk of developing T2DM both without and with polyneuropathy [283].