Based on the results of the bioinformatics study by Sessa et al., the role of miR-21 in cardiovascular diseases is related to its interaction with a number of hub genes: programmed cell death 4 (PDCD4), RAS guanyl-releasing protein 1 (RASGRP1), and B-cell translocation gene 2 (BTG2) (bioinformatics analysis of the experimental data from CVD patients) [211]. This evidence concerns the gene RASGRP1 and cardiovascular disorder.