An association has also been shown between rs12427129 and rs1899663 in lncRNA HOTAIR and the development of diabetic retinopathy [293], the rs2151280-G allele in CDKN2B-AS1 and an increased risk of proliferative diabetic retinopathy, decreased glomerular filtration rate and high-density lipoprotein levels [297], rs55829688 in lncRNA GAS5 and diabetic kidney disease [299], rs2891168 in lncRNA CDKN2B-AS1 and cardiovascular complications in diabetes [298], and rs1333049 in CDKN2B-AS1 and carotid atherosclerosis [294] and HbA1c levels [295]. This evidence concerns the gene CDKN2B and proliferative diabetic retinopathy.