INS and diabetes mellitus: In a high-fat diet-induced diabetes mouse model, whole-transcriptome analysis of pancreatic islets identified novel regulatory axes associated with impaired insulin secretion (miR-6948-5p/Cacna1c, miR-6964-3p/Cacna1b, miR-3572-5p/Hk2, miR-3572-5p/Cckar, and miR-677-5p/Camk2d) and increased pancreatic beta-islet mass (miR-216a-3p/FKBP5, miR-670-3p/Foxo3, miR-677-5p/RIPK1, and miR-802-3p/Smad2 и ENSMUST00000176781/Caspase9) (Table 1) [34].