CASP1 and Hyperglycemia: Li et al. showed that the induction of cardiomyocyte pyroptosis under hyperglycemia under the influence of increased miR-30d expression occurs through an increase in the level of caspase-1 and proinflammatory cytokines IL-1β and IL-18, as a result of a decrease in the expression level of foxo3a and its direct target activity-regulated cytoskeleton-associated protein (ARC) [220].