Two variants in the haplotype associated with PCOS were predicted to have functional consequences based on genomic context: a ERBB3 missense variant (rs773123 https://www.ncbi.nlm.nih.gov/snp/rs773123, accessed on 14 November 2025) and a PA2G4 promoter variant (rs773121 https://www.ncbi.nlm.nih.gov/snp/rs773121, accessed on 14 November 2025) [6]. Here, PA2G4 is linked to polycystic ovary syndrome.