On account of the evidence linking Diaph1 and AGER to actin cytoskeleton malfunctions [2,3,4,5], and thus DPN, we examined the levels of potential protein candidates (Figure 1D) regulated by Diaph1 and AGER/RAGE in the sciatic nerves harvested from mice with six months of T1D (Figure 2A–F). The gene discussed is DIAPH1; the disease is type 1 diabetes mellitus.