Another group also demonstrated that in severe, early-onset preeclampsia, a condition with placental pathology that often overlaps with FGRa/r, PE placentas exhibited more fibrosis-related proteins such as collagens, fibronectin, and α-smooth muscle actin in vivo and in vitro, with preeclamptic stromal FBs being more sensitive to TGFb1 stimulation [78]. This evidence concerns the gene TGFB1 and preeclampsia.