The NephroCheckTM test, which combines TIMP-2 and IGFBP-7, demonstrated AUCs of 0.80–0.82 for AKI prediction in the multi-center SAPPHIRE study [32], while meta-analyses of NGAL in surgical populations have shown pooled AUCs ranging from 0.71 to 0.78 [31,40]. This evidence concerns the gene IGFBP7 and acute kidney injury.