CNR1 and Alzheimer disease: Two-way ANOVA indicated a PEE effect and an interaction between sex and PEE [F (1,29) = 5.632, p < 0.05; F (1,29) = 6.283, p < 0.05; respectively] on Cnr1 mRNA levels, with hippocampal astrocytes from ethanol 3×Tg-AD male offspring showing lower Cnr1 levels than control 3×Tg-AD male offspring (Tukey’s test; * p < 0.05; Figure 2A).