Two-way ANOVA also showed a PEE effect on Mgll and Faah mRNA levels [F (1,28) = 16.17, p < 0.001; F (1,27) = 24.56, p < 0.001; respectively], with a general decrease in the gene expression of these enzymes in the hippocampal astrocytes of ethanol 3×Tg-AD offspring of both sexes compared to their controls (Figure 3C,E). Here, FAAH is linked to Alzheimer disease.