Regarding the enzymatic machinery for endocannabinoid biosynthesis and degradation, an interaction between sex and PEE was found on Daglβ mRNA levels [F (1,31) = 11.52; p < 0.01], with hippocampal astrocytes from ethanol 3×Tg-AD male offspring showing lower Daglβ levels than control 3×Tg-AD male offspring. This evidence concerns the gene DAGLB and Alzheimer disease.