The incubation of sortilin 11H8-MMAE and syndecan-1 6D11-MMAE conjugates with prostate cell lines for 48 h showed increased toxicity in prostate cancer compared to non-malignant cell lines (Figure 7; Supplementary Table S1; e.g., 4.4 nM for 11H8 and 9.2 nM for 6D11 in PC3 cells compared to 44.6 nM for the isotype control). Here, SORT1 is linked to Familial prostate cancer.