This leads to the chronic activation of NF-κB, increased cytokine production—including IL-6, endothelial dysfunction, endothelial-to-mesenchymal transition (EndMT), the proliferation of PASMCs, and immunothrombotic phenomena, which are processes that lead to increased vascular resistance in the pulmonary circulation [188,189,190,191]. Here, IL6 is linked to endothelial dysfunction.