The study results also emphasized that activation of TLR7/8 receptors leads to fatal complications of SLE, such as malignant arterial hypertension and systemic vasculitis in female rats, in which the observed greater susceptibility to the development of autoimmune diseases induced by TLR7 activation may be related to the dose effect—the gene expression of the biallelic X chromosome [140,141,142]. Here, TLR7 is linked to autoimmune disease.