Interestingly, SET (suppressor of variegation, enhancer of zeste, trithorax) and MYND (Myeloid-Nervy-DEAF1) domain containing 3 (SMYD3) is required for TGF-β-induced EMT in HCC cells that are resistant to sorafenib. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.