On the contrary, F-box and WD repeat domain containing 8 (FBXW8) acts as a negative regulator of ZEB1 expression by promoting the proteasomal degradation of Palmitoyl-Protein Thioesterase 1 (PPT1), which is an activator of ZEB1 expression in HCC cells [39]. This evidence concerns the gene PPT1 and hepatocellular carcinoma.