TP53 and colorectal carcinoma: This study aims to (1) characterize the response of AA CRC cell lines to 5-FU and F10, (2) assess the predictive power of MSI and p53 status in fluoropyrimidine sensitivity, (3) investigate transcriptomic differences between AA and CRC cell lines, and (4) explore the potential synergy between F10 and lupeol via the Fas-mediated apoptosis pathway.