The receptors CB1R/CB2R are associated with expression within the intestinal epithelial cells as well as regulation of junction proteins, such as zonula occludens-1 (ZO-1), which regulate intestinal epithelial permeability, as well as translocation of bacterial endotoxins (lipopolysaccharide, LPS, for instance), which reflect a protective strategy, in order to avoid systemic inflammatory response to obesity and metabolic syndrome and septic-related consequences [70,71,72]. Here, CNR1 is linked to obesity due to melanocortin 4 receptor deficiency.