ESM1 and hepatocellular carcinoma: For example, RGCC, SPP1 (osteopontin), GPNMB, and APOE are highly expressed in hepatocellular carcinoma (HCC) [57], whereas PLVAP (PV1) [58], CD276 (B7-H3), and ESM1 are predominantly expressed in glioblastoma (GBM).