Strikingly, several key EEC genes—including chromogranin A (Chga), glucagon (Gcg), neurogenic differentiation 1 (Neurod1), peptide YY (Pyy), and glucagon-like peptide-1 receptor (Glp1r)—were consistently reduced in the AOM/DSS-induced CRC model. Here, GCG is linked to colorectal carcinoma.