The employment of patient-specific MSC lines with this SNPs combination revealed their incompetence to fully complete osteogenic differentiation in vitro, supporting our idea that the homogeneous combination of SNPs in these genes, namely, TSHR rs1991517 (CC), FSHR rs6166 (AA), and ADRB2 rs1042713 (AA), might indeed serve as a prognostic combination for osteoporosis. The gene discussed is TSHR; the disease is osteoporosis.