ADAM17 activity can be triggered by factors such as apoptosis, Ang II, D-glucose, IL-1β, Ca2+ ionophores, fibroblast growth factor 7 (FGF7), protein kinase C (PKC) activators, and purine receptor 2 (P2) agonists during pathogen infection through toll-like receptors (TLRs). The gene discussed is FGF7; the disease is infection.