The expression of FADD, MLKL, TLR2, PGAM, HMGB1, CXCL 1, TRAF2, and EZH2 was elevated in CRC cells, in contrast to FAS, RIPK1, RIPK3, TLR3, TNFRSF, ALDH2, and NDRG2, which presented increased expression in healthy intestinal cells. Here, TLR3 is linked to colorectal carcinoma.