RIGI and infection: Studies have shown that these precursors express pattern recognition receptors (PRRs), including RIG-I (Retinoic Acid-Inducible Gene I), MDA5 (Melanoma Differentiation-Associated protein 5), and TLR3 (Toll-Like Receptor 3) [22,23,24], which are capable of inducing type I interferon (IFN-I) production and the expression of interferon-stimulated genes (ISGs) upon infection [21,25].