In in vitro megakaryocytic models (MEG-01), DENV infection has been reported to induce elevated levels of RIG-I, MDA5, and TLR3 within 48–72 h, accompanied by increased IFN-β expression as early as the first day post-infection [21]—in contrast to the delayed response observed in K562 cells. Here, IFIH1 is linked to infection.