AGT and early-onset autosomal dominant Alzheimer disease: Studies have demonstrated that Angiotensin II (Ang II) induces mitochondrial fragmentation in cardiomyocytes through the activation of Drp1, thereby exacerbating apoptosis In neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, mitochondrial dysfunction and abnormal morphology lead to neuronal apoptosis, which is a significant contributing factor [112].