USP7 and early-onset autosomal dominant Alzheimer disease: In this study, we identified Usp7 and Usp10 as two deubiquitinating enzymes (DUBs) whose downregulation or pharmacological inhibition robustly reduced seeded TAU aggregation in both cortical (CTX) and organotypic hippocampal slice cultures (OHSCs) derived from rTg4510 mice, as well as in wildtype CTX seeded with Alzheimer’s disease (AD)-derived pathological TAU.