DDIT4 and cancer: Previous studies have demonstrated that baicalein inhibits cancer cell proliferation by upregulating the expression of DNA-Damage-Inducible Transcript 4 (DDIT4), which in turn suppresses the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway [11,15].