CCN2, NCF1, and ZNF480 were highly expressed in CSCs from primary CRC tissues, while APOC2, together with A1BG, ADRA1A, ANKS3, C4BPA, DNER, ETDC, EVI2A, F2, FAM71E2, FGG, IDO2, PLA2G4C, SALL1, and TMC3, was predominantly upregulated in liver-metastatic CSCs. The gene discussed is CCN2; the disease is colorectal carcinoma.