Finally, RET improves mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and induces adaptive stress responses such as the upregulation of heat shock proteins (HSPs), contributing to proteostasis and strengthening oligodendrocyte resilience against neurodegeneration in AD [91,98]. The gene discussed is PPARGC1A; the disease is Alzheimer disease.