Figure 8A shows that the combined treatment of PDT with DCA significantly induced caspase-3/-7 activation in PANC-1 cells. While 30 mM DCA alone produced only 11% apoptotic cells, PDT with DCA at 54 J/cm2 nearly tripled this effect (29%). Increasing the laser dose to 108 J/cm2 further enhanced caspase-3/-7 activation to 37%. The results demonstrate that PDT in combination with DCA synergistically induced intrinsic apoptotic cell death in pancreatic cancer cells. Figure 8B shows consolidated data based on Figure 8A. The gene discussed is CASP3; the disease is pancreatic neoplasm.