BECN1 and hereditary clear cell renal cell carcinoma: In several carcinoma models, including renal cell carcinoma 786-O, ACHN, and SASVO3 head-and-neck cells, TQ activates AMPK, leading to downstream mTOR inhibition and increased LC3-II/Beclin-1 expression, consistent with autophagy induction, that culminates in autophagic cell death [37,41].