In another study, TQ was also found to inhibit the expression of chemokine receptor type 4 (CXCR4)—which is associated with increased cell proliferation and metastasis and is an indicator of poor prognosis in patients with breast cancer—in an MDA-MB-231 triple negative breast cancer cell line in a dose- and time-dependent manner. This evidence concerns the gene CXCR4 and triple-negative breast carcinoma.