MAPK8 and prostate cancer: This growth-impeding effect of TQ through ROS generation was also observed in C4-2B and PC-3 prostate cancer cell lines, where consequently, JNK was activated, leading to an increased modulation of GADD45α (DNA damage-inducible gene) and AIF (apoptosis-inducing factor-1), reduced regulation of Bcl-2-associated proteins, and, overall, prostate cancer cell death [21].