NFE2L2 and musculoskeletal system disorder: As an example, in addition to neurodegenerative disorders associated with reduced activity of the Nrf2/NQO1 pathway, other disorders that have been linked with the reduced activity of this pathway include cardiovascular disease [103], hepatic disease [104], renal disease [105], pulmonary disease [106], gastrointestinal disease [107], and musculoskeletal disease [108].