NFE2L2 and early-onset autosomal dominant Alzheimer disease: As noted in Table 3, dysregulation of the Nrf2 pathway is principally associated with neurodegenerative disorders; reduced activity of the Nrf2 pathway is associated with Alzheimer’s disease [98], Parkinson’s disease [99], amyotrophic lateral sclerosis [100], Huntington’s disease [101], and Friedreich’s ataxia [102].