CCL22 and neoplasm: Compared with non-tumor-bearing controls, xenograft-bearing mice exhibited a marked elevation in circulating levels of several analytes, including IL-6, IL-8, IL-10, IL-2, growth-regulated oncogene (GRO), granulocyte colony-stimulating factor (G-CSF), macrophage-derived chemokine (MDC), and vascular endothelial growth factor (VEGF) (Figure 1).