However, in T2DM islets, the number of ligand–receptor interactions increases significantly (rising from 9707 to 10,787), and notable changes occur in β-cell-associated interactions, such as the loss of the C5AR1-RPS19 interaction between β and δ cells, which has been linked to reduced insulin secretion and increased cell apoptosis [121]. This evidence concerns the gene INS and type 2 diabetes mellitus.