MMP9 and neoplasm: Importantly, dormant tumor cells reciprocally modify their own microenvironment through secretion of lysyl oxidase-like protein 2 (LOXL2), Matrix metalloproteinase-9 (MMP9) and CXC Motif Chemokine Ligand 12 (CXCL12) under epigenetic control, enhancing ECM cross-linking and integrin signaling feedback that stabilizes dormancy niches [90].