Cytokines secreted by cancer-associated fibroblasts and macrophages, including Interleukin-6 (IL-6) and Transforming Growth Factor Beta (TGF-β), can activate signal transducer and activator of transcription 3 (STAT3) transcriptional programs that recruit histone modifiers such as EZH2 and HDAC1 to dormancy-associated loci, thereby reinforcing chromatin compaction and the suppression of proliferation-related genes [87,88]. Here, EZH2 is linked to cancer.