Histone demethylase jumonji domain containing protein 2C (JMJD2C), which interacts with HIF-1α, removes repressive H3K9me3 marks, thereby activating the transcription of target genes, which not only promote metastatic lung cancer but may also facilitate the exit of dormant disseminated tumor cells from quiescence, linking hypoxia-driven epigenetic remodeling to both metastasis and dormancy reactivation [126]. This evidence concerns the gene HIF1A and lung cancer.