In lung cancer models, culture on laminin, or collagen IV-rich matrices, that mimic the basement membrane environment, attenuates ERK and AKT signaling, and consequently represses invasive gene expression as well as urokinase-type plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR), [83]. The gene discussed is AKT1; the disease is lung carcinoma.