Since we had shown that the RAS is overexpressed in endometrial cancers [27], we measured expression of RAS genes (REN, AGT, ACE, and AGTR1) in three endometrial cancer cell lines and determined if cell viability and cell proliferation were inhibited by drugs that act to block the activity of the RAS at sites shown in Figure 1. The gene discussed is ACE; the disease is endometrial cancer.