Hao Wang [53] and Abozaid [22] suggested a diagnostic algorithm combining plasma FGF-21 with an additional five markers (CDCP1, FABP4, GDF15, IL-6, THBS2) or 2 (CES1 and IL18-R1) markers, respectively, in diagnostic algorithms for MASH. This evidence concerns the gene THBS2 and metabolic dysfunction-associated steatohepatitis.