In the AML-AF9 leukemia model, the expression of phosphorylated AKT followed by HSC exhaustion was accompanied by a conspicuous increase in myeloid maturation and myeloid maturation-related cell death (the myeloid marker CD11b was higher in bone marrow cells injected with the stem cell virus MSCV (MSCV.IRES-GFP-myr-Akt)). Here, AKT1 is linked to leukemia.