Since JunD co-localizes with CTCF to regulate chromatin compactness, the authors compared RNA-seq and ATAC-seq data between high-JunD and low-JunD CRC cells and normal colon cells, identifying 10 accessible chromatin regions co-enriched with JunD and CTCF that were not present in stem cells. Here, CTCF is linked to colorectal carcinoma.