However, translocation products from AML-ETO, PML-RARα, and PLZF-RARα can activate Wnt signaling via the induction of plakoglobin (γ-catenin), which blocks β-catenin degradation and activates TCF, LEF, and their target c-Myc, thus enhancing cell proliferation and the preservation of immature features [9]. The gene discussed is RARA; the disease is acute myeloid leukemia.