In xenograft models, such as B16F10 melanoma, MDA-MB-231 breast cancer, or PC-3 prostate carcinoma, garcinol inhibits tumor growth by downregulating NF-κB, STAT3, and PI3K/AKT signaling while inducing apoptosis and reducing the cancer stem cell phenotype. The gene discussed is AKT1; the disease is neoplasm.