In the Western Romanian population studied, the risk of deafness is given by pathogenic variants in 7 genes included in the panel: GJB2, USH2A, LOXHD1, SLC26A4, USH1C, COL4A4, COL4A3, present in almost 10% of the cohort, therefore representing a significant risk. Here, COL4A3 is linked to deafness.