Figure 2D shows a higher baseline ALDH activity level in the clonally derived taxane-resistant mCRPC cell line DUTXR compared to the parental line (DU145). This is a significant finding as ALDH is an intracellular enzyme that is frequently overexpressed in cancer stem cells and has been linked to drug resistance. Further, we showed (Figure 2D) that treatment with CLF reduced ALDH activity in the PCa cell lines tested when compared to the no-treatment control. The gene discussed is LDHA; the disease is posterior cortical atrophy.