Notably, using single-cell analysis, we demonstrated that MALAT1 and NEAT1 are enriched in cell subpopulations within all 4 mCRPC cell lines, including the taxane-resistant mCRPC cell line DUTXR, indicating a potential benefit of treating patients with castration-resistant and drug-resistant PCa with Clofazimine. Here, MALAT1 is linked to posterior cortical atrophy.