Beyond its influence on steatosis, the PNPLA3 I148M variant is also linked to more severe liver disease progression, including nonalcoholic steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma [6,26,27,28,29,30,31,32]. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatohepatitis.