TM6SF2 and Hepatic fibrosis: TM6SF2 (Transmembrane 6 Superfamily Member 2) is another key gene, with the rs58542926 C>T variant linked to higher liver fat accumulation by influencing the secretion of very low-density lipoprotein (VLDL) from hepatocytes [50,51,52] as well as liver fibrosis [53].