EGFR and colorectal carcinoma: ISCs exhibit remarkable heterogeneity, regenerative capacity, and plasticity and are influenced by multiple signaling pathways, such as the Notch, Janus kinase/Signal transducer and activator of transcription (Jak/Stat), epidermal growth factor receptor (EGFR), Mechanistic Target of Rapamycin (mTOR), and Decapentaplegic/Bone morphogenetic rotein (Dpp/BMP) pathways, which also play roles in maintaining and renewing the human intestine and are involved in CRC development [48,49,50,51].