Noncoding RNAs (long noncoding RNAs, microRNAs, circular RNAs) act as key regulators of adipogenesis and metabolic pathways: the adipocyte lncRNA lncRAP2 stabilizes adipocyte transcripts, while circMAPK9 and other noncoding RNAs modulate signaling axes such as FTO and MT2A in obesity-associated T2DM. Here, MT2A is linked to obesity due to melanocortin 4 receptor deficiency.