In visceral adipocytes of colorectal cancer patients—particularly when combined with obesity—pathways related to extracellular matrix remodeling, cell adhesion, and transforming growth factor-β (TGF-β) signaling were activated, whereas obesity alone tended to be associated with proinflammatory cascades [35]. This evidence concerns the gene TGFB1 and obesity due to melanocortin 4 receptor deficiency.