STAT3 and obesity due to melanocortin 4 receptor deficiency: For example, bioinformatic comparison of transcriptomes in polycystic ovary syndrome (PCOS), obesity, and T2DM identified jointly dysregulated genes (including IGF2R, the insulin-like growth factor 2 receptor) and network “hub” proteins such as STAT3, IL1B, and PF4 [19].