Together, these results emphasize TRIM28 as a central regulator that shifts the balance from growth factor–driven proliferation (EGFR/PI3K/MAPK) toward cytokine- and stress-related signaling (JAK/STAT, NFκB, TNFα), thereby integrating proliferative control with immune modulation in colorectal cancer cells. The gene discussed is TRIM28; the disease is colorectal cancer.