Currently, strategies to interfere with ABCA1 degradation by regulating calpain activity have become a research focus in the field of atherosclerosis treatment, and multiple studies have confirmed the potential roles of certain substances: for example, piperine [126], zinc ions (Zn2+), and the soluble epoxide hydrolase inhibitor TPPU can all effectively inhibit calpain-mediated ABCA1 degradation [127,128]. Here, ABCA1 is linked to atherosclerosis.