PHB2 and amyotrophic lateral sclerosis: We identified SLP2/PHB2 aggregates in spinal MNs of 2 patients with sporadic ALS (patients 2 and 5, aged 74 and 63, respectively) and 2 patients presenting a C9ORF72-associated ALS (patients 23 and 24, aged 52 and 69, respectively) (Figure 2).