Quantitative analysis showed that control individuals exhibited ~17.7% and ~14.3% of MNs containing SLP2/PHB aggregates, whereas two sporadic ALS patients displayed ~43.5% and ~45.1%, and two C9ORF72 ALS patients showed ~47.6% and ~39.5% of MNs with SLP2/PHB aggregates. Here, PHB1 is linked to amyotrophic lateral sclerosis.