Given that the accumulation of misfolded proteins is a contributing factor to numerous diseases, including cystic fibrosis (CFTR), Parkinson’s disease (a-synuclein), and Alzheimer’s disease (β-amyloid), we utilized A549 (alveolar basal epithelial) and SH-SY5Y (neuroblastoma) cells as models. The gene discussed is CFTR; the disease is early-onset autosomal dominant Alzheimer disease.