ACHE and Alzheimer disease: For example, Eissa et al. synthesized S-substituted tetrahydrobenzothienopyrimidine based on the donepezil scaffold XI and reported dual acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition, antioxidant activity, and suppression of Aβ aggregation—hallmarks of AD pathogenesis [25].