Certain bacteria in subgingival plaques appear to be minimally affected by the factors associated with gingivitis and periodontitis, despite most bacteria exhibiting correlations with IL-1β, endotoxins, TLR-SEAP, TLR-ATP, PAD, MMP-1, MMP-9, GBI, and MGI (Figure 7). Here, PADI4 is linked to gingivitis.